The poor survival rates due to ineffective therapeutic approaches have made gliomas a highly complex and challenging carcinogenic pathological state. Further, Insulin-like growth factor binding protein 2 (IGFBP2) has been reported to have both extracellular and intracellular functions. Moreover, its contribution towards tumor development and progress is not well understood. On the other hand, some studies in the recent past have revealed the roles of both exogenous IGFBP2 treatment as well as IGFBP2 overexpression in the spread of the gliomas. The present review article will refresh the current views of IGFP2 during gliomas.
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