Fusion genes are the result of chromosomal instability where two previously separate genes rearrange and fuse together, forming a hybrid gene. The first fusion gene was reported in a leukemia case but at present many studies have confirmed their existence in several solid tumors. Recent studies have evidenced the influence of fusion genes in glioblastoma too. The fusion genes have been observed to cause activated ERK, STAT3 signaling, that in turn lead to the development of resistance against frontline chemotherapy. The present review article is focused on the current views of fusion genes in glioblastoma.
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