N-methyl-D-aspartate (NMDA) receptors are primarily involved in the rapid excitatory neurotransmission that underlies learning and memory formation. Moreover, NMDA receptors are also implicated in a variety of neurological disorders. Further, studies on allosteric modification of these receptors have resulted in better understanding of NMDA receptor functions and roles that in turn helps in the development of better and efficient drugs. It has been observed in the recent studies that amino terminal domain (ATD) of NMDA is responsible for the conformational changes in the NMDA receptors upon allosteric binding. The present review article aimed to highlight and discuss the recent allosteric modulating approach responsible for modulation of NMDA receptor, important modulators and their influences.
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