OBJECTIVE: This research was designed to compare the therapeutic effects between peripheral vein thrombolysis (PVT) and deep vein catheterization thrombolysis (DVCT) for patients with acute lower-extremity deep vein thrombosis (DVT).
PATIENTS AND METHODS: Medical records from patients receiving PVT or DVCT treatment from January 2014 to December 2014 were collected for analysis. Of the 80 patients included, 33 patients received PVT treatment, while 47 patients received DVCT treatment. The primary outcome measures were patients’ venous patency scores and patency rate. The secondary outcomes measure was the difference in circumference of the same site of the lower limbs (thigh and shank) on the affected-unaffected sides before and after DVT or PVCT treatment. Data on gender, age, course of the disease, cause of the disease, symptoms, length of hospital stay, thrombolysis treatment duration, daily urokinase dosage were also collected and compared.
RESULTS: DVCT had more significant effects in reducing venous patency score than that of PVT treatment (t=3.82, p=0.002). The venous patency rate was 47.0±7.0% for the PVT group, which was significantly lower than 56.0±5.2% in the DVCT group (t=6.70, p<0.001). Both PVT (t=25.91, p<0.001) and DVCT (t=33.06, p<0.001) treatment significantly reduced the differences in circumferences on the affected-unaffected sides of the thigh at time 1 compared with time 0. DVCT treatment significantly diseased the daily urokinase dose by 108.000 U (t=4.56, p<0.001) compared with the PVT treatment. DVCT treatment significantly decreased hospital stay (t=4.13, p<0.001), treatment duration (t=2.49, p=0.015), and daily urokinase dose by 108,000 U (t=4.56, p<0.001) compared with the PVT treatment.
CONCLUSIONS: Deep vein catheterization thrombolysis can significantly increase venous patency rate, and significantly reduce the length of hospital stay, thrombolysis treatment duration, and urokinase use, as compared with peripheral vein thrombolysis treatment.