OBJECTIVE: To study the correlations between the inflammatory responses of acute stress-related mucosal disease (SRMD) and APACHE II score.
PATIENTS AND METHODS: A total of 30 patients diagnosed as SRMD with gastrointestinal bleeding and treated in ICU were successively enrolled in this study. They received drug, endoscopic or surgical hemostasis therapies based on their conditions. The blood loss, APACHE II score, serum C-reactive protein (CRP), malondialdehyde (MDA), transforming growth factor (TGF) β1, interleukin (IL) 1 and IL10 levels were evaluated.
RESULTS: Nine patients (30.0%) died. APACHE II score in the death group was significantly higher than that of survival group. No difference was found in the blood loss when compared. APACHE II score and the blood loss were positively correlated (r=0.387, p=0.034). After 24 h admission CRP, MDA and IL 1 levels were significantly higher in the group who died than those who survived. However, TGFβ1 and IL10 levels were significantly decreased. There was a statistically significant difference (p<0.05). APACHE II score was positively correlated with CRP, MDA and IL 1 levels (r=0.951, p=0.000) and was negatively correlated with TGFβ1 and IL10 levels (r= -0.776, p=0.000).
CONCLUSIONS: After 24 h admission, APACHE II score was closely associated with SRMD prognosis, blood loss and degrees of inflammatory response.