Eur Rev Med Pharmacol Sci 2010; 14 (7): 597-604
Strange formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its oxime derivative – Synthesis, stereochemistry, antibacterial and antifungal activity
V. Kanagarajan, P. Sureshkumar, M. Gopalakrishnan
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University,
Annamalainagar, Tamil Nadu (India)
Pharmacology
Abstract. – Objectives and Methods: A collection of novel N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one oximes 28-32 are synthesized, characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) and two dimensional Noesy spectroscopic data and evaluate for their in vitro antibacterial and antifungal activities.
Results and Conclusion: Compound 32, exerted a wide range of antibacterial activities against the entire tested gram-positive and gram-negative bacterial strains except Escherichia coli, besides compound 30, which is more active against Klebsiella pneumoniae, a gram-negative coccus. Compound 29 exerted strong antifungal activities against Aspergillus flavus and Microsporum gypseum. In addition, compound 32 is more potent against Rhizopus.
Corresponding Author: Mannathusamy Gopalakrishnan, PhD; e-mail: profmgk@yahoo.co.in
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