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Supplement of European Review for Medical and Pharmacological Sciences

Drug-Induced Hepatotoxicity

Guest Editors:

A. Gasbarrini, MD, Internal Medicine Institute and Internal Medicine and Gastroenterology, Catholic University of the Sacred Heart, Rome, Italy

Francesco P. Busardò, MD, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy

A. Grieco, MD, Internal Medicine Institute and Internal Medicine and Gastroenterology, Catholic University of the Sacred Heart, Rome, Italy


Dear Colleagues,

Drugs represent an important cause of liver injury. Presently, almost 1,000 drugs, toxins, and herbs have been reported to cause liver injury and almost 75% of the idiosyncratic drug reactions result in liver transplantation or death. Various types of drug-induced liver diseases are acute-dose dependent liver damage, acute fatty infiltration, cholestatic jaundice, liver granulomas, active chronic hepatitis, liver cirrhosis, liver tumours, etc.

Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. The manifestations of drug-induced hepatotoxicity can be significantly variable, ranging from the asymptomatic elevation of liver enzymes to fulminant hepatic failure. Knowledge of the commonly implicated agents and a high index of suspicion are essential in diagnosis.

Taking into consideration the importance of drug-induced hepatotoxicity as a major cause of liver damage, this supplement throws light on various drugs which induce hepatotoxicity, with their mechanism of liver damage and the related clinical scenario. Moreover, special attention will be focused also on fatalities due to drug-induced hepatotoxicity, by evaluating both the macroscopic findings in the forensic setting and the histological patterns.


Subtopics of interest include, but are NOT limited to:

• Epidemiology of drug-induced liver injury

• Risk factors for drug-induced liver injury

• Pathophysiology and mechanisms of drug-induced liver injury

• Hepatotoxicity associated with illicit use of anabolic androgenic steroids and doping

• Drug of abuse and hepatotoxicity

• Forensic science and toxicology

• Genetic susceptibility to drug-induced liver injury

• Herbal hepatotoxicity

• Dietary supplements

• Role of national registry of drug-induced liver injury


Type of manuscripts:

  • Full and mini-reviews
  • Original and research articles
  • Case reports (if accompanied by a review of the literature of at least 1000 words)



Manuscript submission: 15 September 2016

Peer Review Due: 15 October 2016

Revision Due: 15 November 2016

Notification of acceptance by the Guest Editors: 30 November 2016

Publication within December 2016


Please, submit your manuscript via Publishing Manager at the following link:

All manuscripts must be submitted together with a cover letter where the corresponding Author has to specify that the paper is for the Supplement entitled “Drug-Induced Hepatotoxicity”.

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