OBJECTIVE: MAPK kinase 1 (MEK1), also known as MAP2K1, plays a role in activating extra-cellular signal-regulated protein kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway to regulate cell proliferation and apoptosis. The abnormal expression of MAP2K1 is associated with leukemia. Bioinformatics analysis showed the targeted relationship between microRNA-181a (miR-181a) and the 3’-UTR of MAP2K1. This study aimed … Continue reading miR-181a down-regulates MAP2K1 to enhance adriamycin sensitivity in leukemia HL-60 cells