OBJECTIVE: Ceramide is a lipid molecule that regulates life activities such as cell differentiation, proliferation, apoptosis, and aging. However, whether ceramide plays a role in the intervertebral disc degeneration (IDD) is not clear. The aim of this study is to explore the effect of ceramide during the nucleus pulposus (NP) cells degeneration. PATIENTS AND METHODS: … Continue reading Ceramide accumulation accelerates nucleus pulposus cells degradation by p38MAPK activation