Eur Rev Med Pharmacol Sci 2020; 24 (20): 10319-10329

DOI: 10.26355/eurrev_202010_23379

The role of inflammation in diabetic retinopathy: a review

S. Taurone, M. Ralli, M. Nebbioso, A. Greco, M. Artico, G. Attanasio, M. Gharbiya, A.M. Plateroti, L. Zamai, A. Micera

IRCCS – Fondazione Bietti, Rome, Italy. t.samanta@yahoo.it


OBJECTIVE: Diabetic retinopathy and diabetes represent serious health conditions, being considered among the main causes of blindness. In recent years, anti-VEGF therapies have been of great help in the treatment of retinal pathology and, until now, they represent the primary choice therapy for diabetic retinopathy. Nevertheless, many patients do not experience significant benefits of vision after an anti-VEGF monotherapy. For this reason, several researchers recently focused their attention on the mechanisms that play a central role in the development and progression of diabetic retinopathy.

RESULTS: Available scientific evidence confirms that diabetic retinopathy requires other molecules capable of modifying the mechanisms that, together with angiogenesis, contribute to the development of the condition, such as vascular and neuroinflammation.

CONCLUSIONS: This review summarizes the current knowledge of the pathological changes that occur in diabetic retinopathy and that might contribute to identify possible new strategies for the treatment of this condition.

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To cite this article

S. Taurone, M. Ralli, M. Nebbioso, A. Greco, M. Artico, G. Attanasio, M. Gharbiya, A.M. Plateroti, L. Zamai, A. Micera
The role of inflammation in diabetic retinopathy: a review

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 20
Pages: 10319-10329
DOI: 10.26355/eurrev_202010_23379