Decoding pharmacogenetics and metabolic panels in Jordanian women with polycystic ovary syndrome: a case-control study

A. Yehya, A.M. Rababa'h, J. Hamadneh, C.L. Shaffer

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan. alaa.yehya@yu.edu.jo

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• Pharmacogenomics

OBJECTIVE: This study aimed to assess the metabolic profiles and the frequency of the Serine/threonine kinase 11 (STK11) rs8111699 single-nucleotide polymorphism (SNP) among Jordanian women with polycystic ovary syndrome (PCOS).

MATERIALS AND METHODS Ninety Jordanian women with PCOS and ninety healthy controls participated in the study. Metabolic characteristics were recorded, and direct sequencing was used to identify STK11 SNP genotypes.

RESULTS: Among the PCOS patients, 23 (31.1%) had the wild-type (CC) genotype, while 39 (46.6%) and 28 (35.5%) had heterozygous (CG) and homozygous (GG) genotypes, respectively. There was no statistically significant difference in the genotype and allele distribution between the cases and controls (p=0.264 and p<0.702, respectively). Women carrying the minor G allele had poor metabolic profiles and more severe clinical features.

CONCLUSIONS: The findings support the importance of early detection of PCOS, especially in high-risk populations, to enable timely preventive interventions. The interplay between genetic and metabolic profiles offers guidance for improving treatment outcomes in women with PCOS.

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