Objective: The present pilot trial was carried out to evaluate the effects of an acute treatment with a mixture containing 500 million of Lactobacillus bulgaricus and Streptococcus thermophilus per day in patients with non alcoholic fatty liver disease (NAFLD).
Research Methods: A sample of 30 patients with NAFLD (diagnosed by liver biopsy) was enrolled and 28 patients were analyzed in a double blind randomized clinical trial. Patients were randomized to one of the following treatments during 3 months: group I, treated with one tablet per day with 500 million of Lactobacillus bulgaricus and Streptococcus thermophilus and group II, treated with one placebo tablet (120 mg of starch).
Results: In group I, alanine amino transferase (ALT: 67.7±25.1 vs. 60.4±30.4 UI/L; p < 0.05), aspartate aminotransferase activity (AST: 41.3±15.5 vs. 35.6±10.4 UI/L; p < 0.05) and gammaglutamine transferase levels (gammaGT: 118.2±63.1 vs. 107.7±60.8 UI/L; p < 0.05) decreased. In group II, all liver function parameters remained unchanged (ALT: 60.7±32.1 vs. 64.8±35.5 UI/L; p < 0.05), aspartate aminotransferase activity (AST: 31.7±13.1 vs. 36.4±13.8 UI/L; ns) and gammaglutamine transferase levels (gammaGT: 82.1±55.1 vs. 83.6±65.3 UI/L; ns). Anthropometric parameters and cardiovascular risk factors remained unchanged after treatment in both groups.
Conclusions: A tablet of 500 million of Lactobacillus bulgaricus and Streptococcus thermophilus, with a randomized clinical design, improved liver aminotransferases levels in patients with NAFLD.
Corresponding Author: Daniel A. de Luis MD; e-mail: firstname.lastname@example.orgFree PDF Download
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To cite this article
R. Aller, D.A. de Luis, O. Izaola, R. Conde, M. Gonzalez Sagrado, D. Primo, B. de la Fuente, J. Gonzalez
Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial
Eur Rev Med Pharmacol Sci
Vol. 15 - N. 9