Down-regulation of miR-664 in cervical cancer is associated with lower overall survival

Y.-X. Zhang, L.-L. Qin, S.-Y. Yang

Department of Obstetrics and Gynecology, Rizhao People’s Hospital, Rizhao, Shangdong, China. qinliop0@163.com

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• Oncology

OBJECTIVE: The aim of our study was to explore the clinicopathologic and prognostic significance of microRNA-664 expression in human cervical cancer.

PATIENTS AND METHODS: qRT-PCR was used to determine the expression of miR-664 in cervical cancer tissues. The relationship between miR-664 expression levels in cervical cancer tissues and clinicopathological characteristics was estimated respectively. The survival curves of the patients were determined using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed.

RESULTS: The expression of miR-664 is downregulated in human cervical cancer tissues when compared to the corresponding noncancerous tissues (p < 0.01). Low miR-664 expression was significantly associated with lymphatic invasion (p = 0.000), distant metastasis (p < 0.000), FIGO stage (p = 0.001), and histological grade (p = 0.008). Kaplan-Meier analysis demonstrated that low levels of miR-664 expression were associated with poorer overall survival (p < 0.001). In the multivariate analysis, low miR-664 expression was an independent prognostic factor for OS (p = 0.005).

CONCLUSIONS: MiR-664 may be a promising biomarker for the detection and prognosis evaluation of cervical cancer.

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