Abstract. – Objective: Our aim was to detect whether there is any change in apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the vision, in diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI).
Materials and Methods: Conventional magnetic resonance imaging (MRI) and DWI of the brain were obtained from 45 diabetic patients (15 patients with proliferative diabetic retinopathy (group 1), 15 patients with nonproliferative diabetic retinopathy (group 2), 15 diabetic patients without retinopathy (group 3) and from 15 age-matched healthy volunteers (group 4). ADC values of visual cortex, cingulate gyrus, orbitofrontal, dorsomedial and dorsolateral frontal, corona radiate, and thalamus were obtained.
Results: The ADC values of visual cortex, cingulate gyrus and orbitofrontal cortex significantly increased in groups 1 and 2 compared to groups 3 and 4 (p < 0.001). The ADC values of visual cortex significantly increased in group 1 compared to group 2 (p < 0.001). The duration of disease and value of HbA1c positively correlated with ADC values of the visual and orbitofrontal cortexes, and cingulate gyrus.
Conclusions: We found an increase in ADC values supporting the neuronal loss in some regions, especially in visual center by DWI in the diabetic patients with retinopathy. This result supports the association between diabetic retinopathy and brain injury.
Corresponding Author: Metin Dogan, MD; e-mail: firstname.lastname@example.org
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M. Dogan 1, E. Ozsoy 2, S. Doganay 2, V. Burulday 1, P.G. Firat 2, A. Ozer 3, A. Alkan 4
Brain diffusion-weighted imaging in diabetic patients with retinopathy
Eur Rev Med Pharmacol Sci
Vol. 16 - N. 1