Toxic dermatitis secondary to treatment with collagenase clostridium histolyticum for Dupuytren´s disease

R. Sanjuan-Cervero, J.E. Poquet-Jornet, F.J. Carrera-Hueso

Department of Orthopedic Surgery and Traumatology, Hospital de Denia, Denia – Alicante, Spain. sanjuan.rafcer@gmail.com

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• Pharmacology

OBJECTIVE: Secondary effects and drug reactions relative to collagenase Clostridium histolyticum treatment for Dupuytren’s contracture are frequent. In only a few cases these secondary effects are considered serious. The mechanism that produces these effects of production is not well understood.

CLINICAL REPORT: We present the case report of a woman with fifth finger interphalangeal joint treatment with generalized skin rash as a complication of collagenase Clostridium histolyticum treatment.

DISCUSSION: We discuss treatment, causes and mechanisms of this rare complication from this treatment and review the bibliography about mechanisms for the different types of immunological reactions that may occur after treatment with collagenase Clostridium histolyticum and the possibility of crossed reactions with Clostridiopeptidase A used to treat skin lacerations.

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