Clinical study on influences of enteric coated aspirin on blood pressure and blood pressure variability

A.-L. Ji, W.-W. Chen, W.-J. Huang

Department of Neurology, The Third People Hospital of XuZhou, XuZhou, China. ftmlb8556215@163.com

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• Pharmacology

OBJECTIVE: We investigated the effects of oral administration of enteric coated aspirin (ASA) on blood pressure and blood pressure variability of hypertension patients before sleep.

PATIENTS AND METHODS: We observed 150 hypertension cases, classified as Grade 1-2, from September 2006 to March 2008. They are divided into a control group with 30 cases, ASA I group with 60 cases and ASA II group with 60 cases randomly. Subjects in the control group had proper diets, were losing weight, exercising and maintaining a healthy mentality and were taking 30 mg Adalat orally once a day. Based on the treatment of control group, patients in ASA I group were administered 0.1 g Bayaspirin (produced by Bayer Company) at drought in the morning. Also, based on the treatment of control group, patients in ASA II group were administered 0.1 g Bayaspirin at draught before sleep.

RESULTS: The course of treatment is 3 months and then after the treatment, decreasing blood pressure and blood pressure variability conditions in three groups will be compared. Through the comparison of ASA II group with the control group, they have differences in terms of systolic blood pressure (SBP), diastolic blood pressure (DBP), decreasing range of blood pressure and blood pressure variability (p < 0.05).

CONCLUSIONS: The oral administration of ASA before sleep has synergistic effects on decreasing blood pressure of hypertension patients and improving blood pressure variability.

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