BACKGROUND AND OBJECTIVES: Papaveraceae serve as a rich source of various alkaloids which have anti-inflammatory effect.
MATERIALS AND METHODS: In this study, we investigated the effect of Hylomecon hylomeconoides ethanol extract (HHE) on lipopolysaccharide (LPS)-induced NO and interleukin-6 (IL-6) production in RAW 264.7 cells.
RESULTS: HHE inhibited LPS-induced NO and IL-6 production. Moreover, HHE suppressed the phosphorylation of ERK1/2 and p38 in LPS-induced RAW 264.7 in a dose-dependent manner. Furthermore, major constituents, dihydrosanguinarine and 6-methoxydihydrosanguinarine, of the chloroform-soluble extract were analyzed.
CONCLUSIONS: Taken together, the results of this study indicate that the anti-inflammatory effects of HHE may occur via the inhibition of NO and IL-6 expression through the down-regulation of MAP kinase (ERK1/2, p38) phosphorylation in RAW 264.7 cells.
Corresponding Author: Dong-Yeul Kwon, Ph.D.; e-mail: firstname.lastname@example.org
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H.S. Chae, O.H. Kang, J.H. Keum, S.B. Kim, S.H. Mun, Y.S. Seo, M.R. Kim, J.G. Choi, D.W. Shin*, Y.C. Oh**, J.Y. Ma**, D.Y. Kwon
Anti-inflammatory effects of Hylomecon hylomeconoides in RAW 264.7 cells
Eur Rev Med Pharmacol Sci
Vol. 16 - N. 3 Suppl