Research on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction

Y. Chen, Z. Zhou, X.-X. Li, T. Wang

Department of Gerontology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China. wangtao116848@163.com

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• Pharmacology

OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs.

SUBJECTS AND METHODS: In the cross-sectional study, a total of 2273 university workers (1198 males and 1075 females) aged 22-60 participated. Anthropometric measurements (weight and height), blood pressure, fasting plasma glucose (FPG), lipids, liver and kidney function tests were carried out, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total antioxidant capacity (T-AOC), lipid peroxidation products, malondialdehyde (MDA), advanced oxidation protein products (AOPP) and dityrosine levels were measured.

RESULTS: A further evaluation of oxidative stress markers in subclinical hypothyroidism (SCH) compared with normal thyroid function showed the differences. Among middle-aged men with SCH (n = 467), MDA concentrations (8.11 ± 1.39 nmol/ml) were significantly higher euthyroid controls (7.34 ± 1.31 nmol/ml; n = 190) while AOPP, dityrosine and T-AOC levels were not different.

CONCLUSIONS: It was demonstrated that prevalence of MS components was high. Targeting thyroid hormone restoration, inhibition of ACE and GSK3β via PI3K/AKT signaling pathway using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.

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