Exploring the relationships between inflammatory response and coagulation cascade in inflammatory bowel disease

S. Saibeni, L. Spina, M. Vecchi

Gastroenterology and Gastrointestinal Endoscopy Service, Hepatology Unit, IRCCS Maggiore Hospital and University of Milan – Milan (Italy)

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• Gastroenterology

Abstract. – Background: The inflammatory network and the coagulation cascade are strictly correlated biological systems. Infla-mmatory Bowel Diseases (IBD) are characterised by a prothrombotic state, a hypercoagulability state and an increased prevalence of thromboembolic events. Methods: We reviewed the IBD literature in which the relationships between inflammation and coagulation were evaluated. Results: Several risk factors and mechanisms have been suggested to be implicated in determining the increased risk for thrombosis of IBD. Even if IBD may be per se a prothrombotic condition, systemic inflammation and vitamin deficiencies appear to play a relevant role in determining such a risk. Conclusions: A good and continuous control of the intestinal disease and vitamin supplementation are strongly recommended in order to correct some of the risk factors for thrombosis in IBD patients.

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