The expression of OCT4 and its clinical significance in laryngeal squamous carcinoma tissues

H.-Y. Chen, X.-L. Han, R.-G. Wang, X.-F. Song, H.-Z. Zhang

Department of ENT and Department of Oncology; Hebei General Hospital, Shijiazhuang City, China. lm3493853@163.com

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• Oncology

OBJECTIVE: To investigate the expression of OCT4 and its clinical significance in laryngeal squamous carcinoma tissues.

PATIENTS AND METHODS: Immunohistochemical staining was used to analyze the expression of OCT4 in 61 cases of laryngeal squamous carcinoma and 10 cases of the adjacent normal laryngeal tissues.

RESULTS: The expression of OCT4 was not detected in normal laryngeal tissues, but could be detected in the nucleus of laryngeal carcinoma. The positive expression rates of OCT4 in well-moderately differentiated and poorly differentiated laryngeal squamous carcinoma tissues were 25.6% (11/43) and 66.7% (12/18) respectively, and there were significant differences (p < 0.01). The expression of the OCT4 protein was related to lymph node metastasis and TNM stage (p < 0.05), but not to gender, age and position of the tumor (p > 0.05).

CONCLUSIONS: OCT4 is expressed in laryngeal squamous carcinoma tissues and is closely related to the cell differentiation of laryngeal carcinoma, lymph node metastasis and clinical stage.

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