Eur Rev Med Pharmacol Sci 2018; 22 (6): 1860-1872

DOI: 10.26355/eurrev_201803_14607

The cardiovascular macrophage: a missing link between gut microbiota and cardiovascular diseases?

X. Chen, L. Zheng, Y.-Q. Zheng, Q.-G. Yang, Y. Lin, F.-H. Ni, Z.-H. Li

International Medical Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang Province, China. chenxi@hmc.edu.cn


The prevalence of cardiovascular diseases is on the rise. Interventions that would aid prevention or treatment of these diseases are essential. The microbes residing in the gut, collectively called “gut microbiota”, produce a plethora of compounds that enter the bloodstream and affect the cardiovascular system. Signals ascending from gut microbiome are believed to modulate differentiation and functional activity of macrophages residing in perivascular tissue, atherosclerotic plaques, and perivascular areas of the brain. Cardiovascular macrophages may be the key players that transform the signals ascending from gut microbiome into increased predisposition to cardiovascular diseases. The present review summarizes the knowledge to date on potential relationships between gut microbiota, cardiovascular macrophages, and cardiovascular diseases.

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To cite this article

X. Chen, L. Zheng, Y.-Q. Zheng, Q.-G. Yang, Y. Lin, F.-H. Ni, Z.-H. Li
The cardiovascular macrophage: a missing link between gut microbiota and cardiovascular diseases?

Eur Rev Med Pharmacol Sci
Year: 2018
Vol. 22 - N. 6
Pages: 1860-1872
DOI: 10.26355/eurrev_201803_14607