LncRNALUADT1 is overexpressed in colorectal cancer and its expression level is related to clinicopathology

X.-F. Zhang, Y. Zhang, Z. Shen, G.-G. Yang, H.-D. Wang, L.-F. Li, D.-C. Liu, J.-M. Qiu

Department of Coloproctology, The Hangzhou Third Hospital, Hangzhou, China. shenzhong114@sina.com

---

• Oncology

OBJECTIVE:  LncRNAs participate in the proliferation, apoptosis, and invasion of colorectal cancer. We aimed at investigating the uncovered effect of lncRNALUADT1 on colorectal cancer.

PATIENTS AND METHODS: The relative expression level of lncRNALUADT1 in tumor specimen was tested by Real-time quantitative PCR. The association of lncRNALUADT1 with clinical pathological data was analyzed by univariate, multivariate Cox and Kaplan-Meier curve.

RESULTS: LncRNALUADT1 expression was up-regulated in colorectal cancer, and correlated with tumor size, metastasis, and TNM staging. Both univariate analysis and multivariate test indicated that lncRNALUADT1 high expression, TNM staging, and lymph node metastasis were closely related. Moreover, high expression of lncRNALUADT1 suggested the poor overall survival of patients.

CONCLUSIONS: LncRNA LUADT1 might contribute to the development of colorectal cancer.

Free PDF Download