Rs13405728 is associated with slow ovarian response in assisted reproductive technology

Q.-Q. Yin, J.-H. Zheng, J. Huang, Y.-J. Cao, B. Zhang, D.-Z. Yang

Center for Reproductive Medicine, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, Jiangsu, China. yangdz@mail.sysu.edu.cn

---

• Obstetrics

OBJECTIVE: To explore the association between rs13405728 with slow ovarian response in assisted reproductive technology (ART).

PATIENTS AND METHODS: 236 women, aged 21 to 35 years, were enrolled and grouped according to their genotypes, The polymorphism of rs13405728 was genotyped by DNA sequencing.

RESULTS: There was no evidence of any difference in anti-Müllerian hormone (AMH), antral follicle count (AFC) among the three genotypes (p>0.05). The occurrence of slow response in genotype GG was lower than those in the other two genotypes (p<0.05). There were independent correlations between slow ovarian response with the dose of luteinizing hormone (LH) required and the genotypes of rs13405728 (p<0.05).

CONCLUSIONS: There were significant independent correlations between slow ovarian response with the dose of LH required and the genotypes of rs13405728. Different mechanisms may be involved in poor response and slow response.

Free PDF Download