Eur Rev Med Pharmacol Sci 2018; 22 (16): 5187-5193

DOI: 10.26355/eurrev_201808_15715

Serum miR-629 is a novel molecular marker for diagnosis and the prognosis of pancreatic cancer

W. Shi, Y. Lu, R. Gong, J.-J. Sun, G. Liu

Department of Hepatopancreatobiliary Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China. Peisw721@163.com


OBJECTIVE: Increasing evidence indicates that dysregulation of miRNAs is involved in tumor progression and development. We aimed to determine potential values of miR-629 as a serum diagnostic and prognostic biomarker in pancreatic cancer (PC).

PATIENTS AND METHODS: MiR-629 expression levels in PC tissues and serum were measured by quantitative Real-time reverse transcription-polymerase chain reaction (qRT-PCR). Receiver operating characteristic analysis (ROC) was utilized to assess the predictive power of serum miR-629 for PC. Then, the associations of serum miR-629 expression levels with clinicopathological features and prognosis were evaluated.

RESULTS: We found that the expression levels of miR-629 were significantly upregulated in both PC tissues and serum in comparison with matched normal tissues and healthy controls, respectively. Importantly, serum miR-629 could efficiently screen PC patients from healthy controls (AUC=0.765). The diagnosis capability of serum miR-629 was significantly higher than that of CA19-9, and the combination of two molecules had higher diagnosis capacity. Higher expression of serum miR-629 in PC patients was associated with advanced TNM stage (p=0.000) and distant metastasis (p=0.003). Moreover, Kaplan-Meier analysis indicated that patients with high expression of serum miR-629 had significantly shorter overall survival (p=0.0022) and disease-free survival (p=0.0003) than the low expression group. Univariate and multivariate analysis showed that serum miR-629 was a significant and independent prognostic predictor for both overall survival and disease-free survival of PC patients.

CONCLUSIONS: This study suggested serum miR-629 may be a potential biomarker for the diagnosis and prognosis of PC.

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To cite this article

W. Shi, Y. Lu, R. Gong, J.-J. Sun, G. Liu
Serum miR-629 is a novel molecular marker for diagnosis and the prognosis of pancreatic cancer

Eur Rev Med Pharmacol Sci
Year: 2018
Vol. 22 - N. 16
Pages: 5187-5193
DOI: 10.26355/eurrev_201808_15715