Eur Rev Med Pharmacol Sci 2018; 22 (19): 6567-6572

DOI: 10.26355/eurrev_201810_16073

Effects of myo-inositol on glucose variability in women with gestational diabetes

B. Pintaudi, G. Di Vieste, F. Corrado, G. Lucisano, L. Giunta, R. D’Anna, A. Di Benedetto

Diabetes Unit, Niguarda Cà Granda Hospital, Milan, Italy. basilio.pintaudi@ospedaleniguarda.it


OBJECTIVE: Myo-inositol supplementation prevents gestational diabetes (GDM) in women at risk and reduces insulin resistance in women with GDM. No data are available about its effect on glucose variability. The aim of this study was to evaluate the effects of a supplementation of myo-inositol on glucose variability in women with GDM.

PATIENTS AND METHODS: Myo-inositol effect on glucose variability was studied in a pilot case-control study involving 12 consecutive pregnant women (median age 34 years, 25.0% insulin-treated) with GDM. Six women received myo-inositol 2 g plus 200 mg folic acid twice a day, the others received only folic acid. Information on side effects was collected. A continuous glucose monitoring system was wore before and at the beginning of the supplementation. Mean amplitude of glucose excursion (MAGE), standard deviation (SD) and variability coefficient were the indexes of glucose variability.

RESULTS: Myo-inositol lowered glucose levels in the first days after the treatment was started. However, pre-post supplementation overall mean glucose difference was similar between groups (-4.8 vs. 5.0 mg/dL for controls and treated, respectively; p = 0.79). Pre-post differences in SD (13.7 vs. 6.0; p < 0.001), MAGE (3.5 vs.-1.5; p < 0.001) and variability coefficient (0.14 vs. 0.02; p < 0.001) were improved in myo-inositol group. No side effects were recorded.

CONCLUSIONS: Myo-inositol is effective in reducing glucose variability in women with GDM. It could be a useful strategy for treating GDM.

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To cite this article

B. Pintaudi, G. Di Vieste, F. Corrado, G. Lucisano, L. Giunta, R. D’Anna, A. Di Benedetto
Effects of myo-inositol on glucose variability in women with gestational diabetes

Eur Rev Med Pharmacol Sci
Year: 2018
Vol. 22 - N. 19
Pages: 6567-6572
DOI: 10.26355/eurrev_201810_16073