Eur Rev Med Pharmacol Sci 2018; 22 (20): 7024-7033

DOI: 10.26355/eurrev_201810_16174

Optimising management of patients with hepatitis C virus in the age of direct-acting antivirals: results of a Delphi consensus

V. Di Marco, A. Alberti, G. Angarano, M. Colombo, G. Di Perri, G.B. Gaeta, G. Ippolito, A. Mangia, P. Pasqualetti, A. Craxì

Sezione di Gastroenterologia e Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy. vito.dimarco@unipa.it


OBJECTIVE: To optimize the management of patients with chronic hepatitis C virus (HCV).

MATERIALS AND METHODS: We developed two questionnaires to determine Italian healthcare professionals’ opinions on the overall management of HCV chronic liver disease and the use of direct-acting antivirals (DAAs) in the treatment of HCV. A Delphi consensus method using the RAND/UCLA appropriateness method was used to determine opinions of an expert panel (EP) of specialists.

RESULTS: Overall 443 physicians from 167 Italian centres completed the two questionnaires. The EP confirmed the importance of collaboration with general practitioners (GPs) and HCV testing in high-risk groups, but did not agree on treating patients over 80 years of age with DAAs. Over 90% agreed that it was important to quantify HCV-RNA, determine genotype, and test for anti-HIV and HBsAg before starting DAAs. Transient elastography (FibroScan®) was used by >90% to evaluate the stage of liver fibrosis while serum biomarkers were used by <20%. Adherence to therapy, drug-drug interactions and the possibility of treating advanced liver disease were decisive factors in therapy choice. Monthly monitoring during therapy was considered appropriate and 80% were in favor of HCV-RNA testing 24 weeks after the end of the therapy to confirm sustained virological response (SVR). Over 80% agreed that it was necessary to continue follow-up of patients with advanced fibrosis/cirrhosis.

CONCLUSIONS: Scientific organizations should review their guideline recommendations to facilitate access to DAAs.

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V. Di Marco, A. Alberti, G. Angarano, M. Colombo, G. Di Perri, G.B. Gaeta, G. Ippolito, A. Mangia, P. Pasqualetti, A. Craxì
Optimising management of patients with hepatitis C virus in the age of direct-acting antivirals: results of a Delphi consensus

Eur Rev Med Pharmacol Sci
Year: 2018
Vol. 22 - N. 20
Pages: 7024-7033
DOI: 10.26355/eurrev_201810_16174