Eur Rev Med Pharmacol Sci 2019; 23 (2 Suppl): 271-278

DOI: 10.26355/eurrev_201904_17501

Infection in orthopaedic oncology: crucial problem in modern reconstructive techniques

G. Trovarelli, A. Angelini, E. Pala, A. Cappellari, A. Breda, P. Ruggieri

Department of Orthopaedics and Orthopaedic Oncology, University of Padova, Padova, Italy. pietro.ruggieri@unipd.it


OBJECTIVE: Infection after orthopaedic oncology surgery is a relatively frequent complication. Infection rate ranges in the literature between 3.7% and 19.9%, increasing up to 47% after pelvic resection and reconstruction. It represents a challenging topic when occurring in oncologic patients because of the delay of systemic and local treatments, influencing prognosis. Infection is a major concern in terms of both prevention and treatment. The aim of our review was to analyze data reported in the literature about strategies and new materials for infection prevention in musculoskeletal oncology surgery.
MATERIALS AND METHODS: We reviewed the literature focusing on the use of new materials that can reduce the risk of infection, avoiding biofilm formation on the implant surface.
RESULTS AND DISCUSSION: New materials are available to try to reduce the risk of infection. Iodine-coating, DAC-coating or silver-coating, are the more promising technologies available at today. Initial results with DAC-coating in non-oncological patients are interesting; however, studies about its efficacy in preventing infection in orthopaedic oncology are not present in literature. On the other side, iodine-coating implants or silver-coating prostheses demonstrated efficacy against early infections, associated with lower risk of implant removal and amputation as final surgery.
CONCLUSIONS: Post-operative infections in orthopaedic oncology surgery are still frequent, and their diagnosis and treatment are demanding. According to the literature, silver-coated prostheses should be considered as the best option in case of revision surgery due to infection. However, there is no evidence that these new materials are effective to decrease the risk of infection drastically. Further studies with numerous series and long-term follow up are required.

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To cite this article

G. Trovarelli, A. Angelini, E. Pala, A. Cappellari, A. Breda, P. Ruggieri
Infection in orthopaedic oncology: crucial problem in modern reconstructive techniques

Eur Rev Med Pharmacol Sci
Year: 2019
Vol. 23 - N. 2 Suppl
Pages: 271-278
DOI: 10.26355/eurrev_201904_17501