OBJECTIVE: To investigate the correlation of osteoporosis (OP) with matrix metalloproteinase-1 (MMP-1) gene polymorphism.
PATIENTS AND METHODS: A total of 199 patients as observation group (OP) and 180 healthy subjects (control group) were enrolled in the study, and the general data, the expression levels of serum calcium, serum phosphate and MMP-1 were collected and determined. The bone mineral density was determined using a bone sonometer, and the method of TaqMan-MGB probe was adopted for the detection of gene polymorphism of MMP-1 rs494379.
RESULTS: The level of serum calcium and bone mineral density were lower in observation group than those in control group (p>0.05), while the levels of serum phosphate and MMP-1 were higher than those in control group (p>0.05). There were differences in rs494379 genotype and allele in MMP-1 gene between the two groups (p<0.05). In the analysis of the genetic model, the dominant models between the two groups were different (p<0.05), while there were no differences in the recessive model and additive model (p>0.05). The MMP-1 level was higher in rs494379 AA genotype than that in GG, GT genotype in MMP-1 gene.
CONCLUSIONS: Gene polymorphism of MMP-1 rs494379 has a correlation with the occurrence of OP.Free PDF Download
To cite this article
L. Liang, D.-P. Zhu, S.-S. Guo, D. Zhang, T. Zhang
MMP-1 gene polymorphism in osteoporosis
Eur Rev Med Pharmacol Sci
Vol. 23 - N. 3 Suppl