Eur Rev Med Pharmacol Sci 2019; 23 (22): 9923-9930

DOI: 10.26355/eurrev_201911_19558

Implant placement in oral squamous cells carcinoma patients treated with chemoradiotherapy: “Sapienza Head and Neck Unit” clinical recommendations

E. Brauner, D. Musio, S. Mezi, A. Ciolfi, F. Maghella, A. Cassoni, F. De Angelis, G. Guarino, U. Romeo, G. Tenore, G. Piesco, F. De Felice, V. Tombolini, V. Valentini, A. Polimeni, S. Di Carlo

Department of Oral and Maxillofacial Sciences, Sapienza Università di Roma, Rome, Italy. alessandro5ciolfi@gmail.com


OBJECTIVE: To date, the treatment of patients affected by head and neck squamous cell carcinoma (HNSCC) is highly challenging for clinicians. Possible therapies are surgical resection of the tumor mass, radiotherapy, chemotherapy or, more often, a combined treatment that inevitably affects both normal and tumor cells. Consequently, patients’ anatomy and functions become reduced or altered. Nowadays the functional restoration is significantly improved thanks to the innovation in prosthetic rehabilitation and in radiotherapy. The current IMRT (Intensity Modulated Radiation Therapy) allows planning adequate treatments evaluating different tissues’ involvement and radiation dosage. It is possible to define the most suitable sites for implant insertion, using data provided by dose-volume histogram (DVH). This study aims to illustrate the idea of obtaining a unique CT image by blending radiation-planning CT and Cone Beam CT.
PATIENTS AND METHODS: Five patients among 54 candidates were selected for this study. Selection criteria were: good general health (PS0-1), age between 18 and 72 years, absence of metastatic disease or local recurrence, disease-free interval of at least 18 months. Radiation planning CT scan and maxillo-facial CT Cone Beam of every patient were overlapped and merged. Only one CT for every evaluated patient was obtained in order to plan the most suitable areas for implant placement.
RESULTS: The placement of 10 implants in 5 patients was programmed using the explained method. Patients (all male) were aged between 48 and 72 years old, with a median age of 64.4 years. In every case of this study, a modification of the initial program of implant placement was necessary. The new imaging method we are proposing was able to provide information about radiation isodoses received in the planned osseointegrated implants’ positions.
CONCLUSIONS: This new method allows operators to correct their own therapy plans and choices, customizing the treatment plan on the actual condition of the patient. Moreover, it makes all the rehabilitation process safer and can reduce the risk of failure, side effects and inconveniences for the patients.

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E. Brauner, D. Musio, S. Mezi, A. Ciolfi, F. Maghella, A. Cassoni, F. De Angelis, G. Guarino, U. Romeo, G. Tenore, G. Piesco, F. De Felice, V. Tombolini, V. Valentini, A. Polimeni, S. Di Carlo
Implant placement in oral squamous cells carcinoma patients treated with chemoradiotherapy: “Sapienza Head and Neck Unit” clinical recommendations

Eur Rev Med Pharmacol Sci
Year: 2019
Vol. 23 - N. 22
Pages: 9923-9930
DOI: 10.26355/eurrev_201911_19558