Eur Rev Med Pharmacol Sci 2020; 24 (11): 6333-6337

DOI: 10.26355/eurrev_202006_21531

Expression level of lncRNA PVT1 in serum of patients with coronary atherosclerosis disease and its clinical significance

W. Quan, P.-F. Hu, X. Zhao, C.-G. Lianhua, B.-R. Batu

Department of Cardiovascular, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China. wanquan120@126.com


OBJECTIVE: The purpose of this study was to detect the expression level of PVT1 in the serum of coronary artery disease (CAD) patients, and to explore the clinical significance of PVT1 in CAD.

PATIENTS AND METHODS: A total of 200 CAD patients and 200 healthy controls in the same period were included. The serum level of PVT1 in every subject was detected. Then, the correlation between PVT1 level and Gensini score in CAD patients was analyzed by Spearman correlation test. Finally, multivariable Logistic regression test was conducted to assess risk factors influencing coronary atherosclerosis disease.

RESULTS: It was found that PVT1 was highly expressed in the serum of CAD patients and its level was correlated with Gensini score (r=0.761, p=0.023). Besides, multivariable Logistic regression test obtained that PVT1 was the risk factor influencing coronary atherosclerosis disease (crude OR = 2.074, 95% CI: 1.642-3.529; adjusted OR = 1.762, 95% CI: 1.382-2.096).

CONCLUSIONS: Serum level of PVT1 helps to distinguish mild and severe CAD. Meanwhile, PVT1 is an independent risk factor influencing the development of coronary atherosclerosis disease.

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To cite this article

W. Quan, P.-F. Hu, X. Zhao, C.-G. Lianhua, B.-R. Batu
Expression level of lncRNA PVT1 in serum of patients with coronary atherosclerosis disease and its clinical significance

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 11
Pages: 6333-6337
DOI: 10.26355/eurrev_202006_21531