Eur Rev Med Pharmacol Sci 2021; 25 (3): 1399-1409

DOI: 10.26355/eurrev_202102_24848

Emerging role of lncRNA DANCR in progenitor cells: beyond cancer

Z. Zhang, L. Shu, M. Hu, X. Zhou, F. Yang, X.-H. Zhou

College of Basic Medicine, Second Military Medical University, Shanghai, China. yangfusq1997@smmu.edu.cn


Long noncoding RNAs (lncRNAs) are important participants in biological processes including cell proliferation, differentiation and death, as well as pathogenesis of various diseases. LncRNA differentiation antagonizing non-protein coding RNA (DANCR) is an emerging regulator in cell metabolism and many diseases besides cancers. DANCR is negative in epidermal, osteoblastic and endoderm differentiation, but positive in chondrogenic differentiation of progenitor cells. It is protective for calcification of the ligamentum flavum, stroke, acute myocardial infarction and arterial calcification, but a risk factor for bone loss, fracture healing and idiopathic pulmonary fibrosis. In addition, DANCR is a potential target for improving tissue regeneration. Mechanically, DANCR, a cytoplasmic lncRNA, sponges corresponding microRNAs or interacts with various proteins. This review aims to summarize the role of DANCR in progenitor cells and provide perspectives for further studies.

 

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To cite this article

Z. Zhang, L. Shu, M. Hu, X. Zhou, F. Yang, X.-H. Zhou
Emerging role of lncRNA DANCR in progenitor cells: beyond cancer

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 3
Pages: 1399-1409
DOI: 10.26355/eurrev_202102_24848