Eur Rev Med Pharmacol Sci 2021; 25 (3): 1425-1435

DOI: 10.26355/eurrev_202102_24850

Impact of miR-155 (rs767649 A>T) and miR-146a (rs57095329 A>G) polymorphisms in System Lupus Erythematosus susceptibility in an Egyptian cohort

S.R. Mohammed, O.G. Shaker, A.A. Mohammed, N.A. Fouad, H.A. Hussein, N.A. Ahmed, O.M. Ahmed, D.Y. Ali, M.M. Mohamed, A.A. Ibrahim

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. Srk00@fayoum.edu.eg

 

 


OBJECTIVE: Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disease. miR-155 and miR-146a were expressed in many autoimmune diseases such as rheumatoid arthritis. The aim of this study was to examine miR-155 rs767649 and miR-146a rs57095329 polymorphisms in SLE susceptibility in an Egyptian cohort and to investigate the correlation between them and clinical data and disease activity.

PATIENTS AND METHODS: The two SNPs were analyzed in 120 patients with SLE and 100 healthy controls using RT-PCR.

RESULTS: The TT genotype and T allele of miR-155 rs767649 were associated with a significant increase in the risk of SLE, particularly in females. On the other hand, miR-146a (rs57095329) polymorphism was not associated with SLE risk. The AT/TT genotypes of miR-155 rs767649 showed higher distributions among patients with higher SLEDAI and nephritis.

CONCLUSIONS: This study had demonstrated for the first time the association between miR-155 rs767649 and the risk of development of SLE in an Egyptian cohort, mostly in females.

 

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S.R. Mohammed, O.G. Shaker, A.A. Mohammed, N.A. Fouad, H.A. Hussein, N.A. Ahmed, O.M. Ahmed, D.Y. Ali, M.M. Mohamed, A.A. Ibrahim
Impact of miR-155 (rs767649 A>T) and miR-146a (rs57095329 A>G) polymorphisms in System Lupus Erythematosus susceptibility in an Egyptian cohort

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 3
Pages: 1425-1435
DOI: 10.26355/eurrev_202102_24850