Eur Rev Med Pharmacol Sci 2021; 25 (3): 1622-1630

DOI: 10.26355/eurrev_202102_24873

Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment

J.-Y. Chen

Xiehe Biology Group, Nobel Institute of Medicine, Shenzhen, Guangdong Province, China. jyC318@163.com


OBJECTIVE: Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs. However, the intrinsic toxicity of natural SAgs stimulated the development of more effective and less toxic SAg-based immunotherapy. This review summarizes our current knowledge on SAg-based immunotherapy including SAg-like proteins and SAg derivatives, as well as their potential alone or with other therapeutic modalities including chemotherapy and radiotherapy.

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To cite this article

J.-Y. Chen
Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 3
Pages: 1622-1630
DOI: 10.26355/eurrev_202102_24873