Eur Rev Med Pharmacol Sci 2021; 25 (3): 1641-1649

DOI: 10.26355/eurrev_202102_24875

The important role of TFEB in autophagy-lysosomal pathway and autophagy-related diseases: a systematic review

T.-T. Song, R.-S. Cai, R. Hu, Y.-S. Xu, B.-N. Qi, Y.-A. Xiong

School of Pharmacy, Zunyi Medical University, Xinpu District, Zunyi, Guizhou, China. 625221174@qq.com


Autophagy is a main metabolic process in which eukaryotic cells use lysosomes to eliminate abnormal proteins and damaged organelles to maintain cell homeostasis. Studies have revealed that neurodegenerative diseases, tumor, hepatic diseases, etc. are related to abnormal autophagy processes in recent years. Recent studies have shown that TFEB is a major transcription regulator of autophagy-lysosomal pathway (ALP) transcriptional regulation, which positively regulates the expression of autophagy and lysosomal biogenesis-related genes, thereby promoting autophagosome formation, autophagosome-lysosome fusion, and degradation of autophagy substrates. It has also been found that TFEB promotes clearance of intracellular substrates through lysosomal exocytosis. Therefore, the study of biological functions and related regulatory mechanisms of TFEB will provide important clues and theoretical basis for further explaining its physiological pathogenesis and the treatment of related diseases.

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To cite this article

T.-T. Song, R.-S. Cai, R. Hu, Y.-S. Xu, B.-N. Qi, Y.-A. Xiong
The important role of TFEB in autophagy-lysosomal pathway and autophagy-related diseases: a systematic review

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 3
Pages: 1641-1649
DOI: 10.26355/eurrev_202102_24875