Eur Rev Med Pharmacol Sci 2021; 25 (13): 4579-4596

DOI: 10.26355/eurrev_202107_26251

Fusobacterium nucleatum and alteration of the oral microbiome: from pregnancy to SARS-COV-2 infection

A. Dessì, A. Bosco, R. Pintus, G. Orrù, V. Fanos

Neonatal Intensive Care Unit, University Hospital of Cagliari, Monserrato, Cagliari, Italy. angelicadessi@hotmail.it


OBJECTIVE: The human being has evolved in close symbiosis with its own ecological community of commensal, symbiotic and pathogenic bacteria. After the intestinal microbiome, that of the oral cavity is the largest and most diversified. Its importance is reflected not only in local and systemic diseases, but also in pregnancy since it would seem to influence the placental microbiome.

MATERIALS AND METHODS: This is a literature review of articles published in PubMed about Fusobacterium Nucleatum and both its implications with systemic and oral health, adverse pregnancy outcomes, flavors perception and its interference in the oral-nasal mucosal immunity.

RESULTS: It is in maintaining the microbiome’s homeostasis that the Fusobacterium nucleatum, an opportunistic periodontal pathogen of the oral cavity, plays a crucial role both as a bridge microorganism of the tongue biofilm, and in maintaining the balance between the different species in the oral-nasal mucosal immunity also by taste receptors interaction. It is also involved in the flavor perception and its detection in the oral microbiome of children from the first days of life suggests a possible physiological role. However, the dysbiosis can determine its pathogenicity with local and systemic consequences, including the pathogenesis of respiratory infections.

CONCLUSIONS: It is interesting to evaluate its possible correlation with Sars-CoV-2 and the consequences on the microflora of the oral cavity, both to promote a possible broad-spectrum preventive action, in favor of all subjects for whom, by promoting the eubiosis of the oral microbiome, a defensive action could be envisaged by the commensals themselves but, above all, for patients with specific comorbidities and therefore already prone to oral dysbiosis.

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To cite this article

A. Dessì, A. Bosco, R. Pintus, G. Orrù, V. Fanos
Fusobacterium nucleatum and alteration of the oral microbiome: from pregnancy to SARS-COV-2 infection

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 13
Pages: 4579-4596
DOI: 10.26355/eurrev_202107_26251