Eur Rev Med Pharmacol Sci 2021; 25 (18): 5766-5768

DOI: 10.26355/eurrev_202109_26794

Oral desensitization in egg acute food protein-induced enterocolitis syndrome

S. Miceli Sopo, D. Sinatti, M. Gelsomino

Pediatric Allergy Unit, Pediatrics Section, Department of Life Sciences and Public Health, Policlinico Gemelli University Foundation IRCCS, Catholic University of the Sacred Heart, Rome, Italy. dario.sinatti01@icatt.it; dsinatti@gmail.com


OBJECTIVE: Strict avoidance of trigger food is the primary management of food protein-induced enterocolitis syndrome (FPIES). No published data are available on active induction of tolerance with oral desensitization (OD) in FPIES.

CASE REPORT: We carried out an OD in a 9 and a half years old boy with persistent acute egg FPIES. OD was performed with increasing doses of raw egg every week, starting with an initial dose of 0.2 ml. The boy presented mild and transient gastrointestinal adverse reactions when the 4 ml dose was reached. He could tolerate a whole raw egg in less than 14 months.

CONCLUSIONS: Even though randomized controlled clinical trials on patients including various phenotypes of FPIES are needed, our experience is encouraging about the possible efficacy and safety of OD in this food allergy.

 

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To cite this article

S. Miceli Sopo, D. Sinatti, M. Gelsomino
Oral desensitization in egg acute food protein-induced enterocolitis syndrome

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 18
Pages: 5766-5768
DOI: 10.26355/eurrev_202109_26794