Eur Rev Med Pharmacol Sci 2021; 25 (23): 7398-7401

DOI: 10.26355/eurrev_202112_27436

Spastic paraplegia as the only manifestation in neuropsychiatric lupus: a case report

X. Peng, Z. Xiao, L. Wang

Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. wang0128_0@163.com


Demyelination syndrome is one manifestation of neuropsychiatric lupus erythematosus (NPLE) and is rare in systemic lupus erythematosus (SLE). When SLE presents only neuropsychiatric symptoms without damage to other systems, its diagnosis becomes difficult. Herein, we report a 29-year-old male who suffered from lower limb stiffness with recessive onset and progressive aggravation in one year. He had paraplegia, spastic hypertonia, abnormal gait, and bilateral positive Babinski signs. His symptoms indicated spastic paraplegia. Brain MRI showed multiple small demyelinating lesions in the lateral ventricle, brainstem, and cerebellum. Anti-ds DNA, anti-Sm and anti-RNP antibodies were positive. He was diagnosed with NPLE and had a good treatment response to steroids. To the best of our knowledge, this is the first case of spastic paraplegia as the only manifestation in SLE.

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To cite this article

X. Peng, Z. Xiao, L. Wang
Spastic paraplegia as the only manifestation in neuropsychiatric lupus: a case report

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 23
Pages: 7398-7401
DOI: 10.26355/eurrev_202112_27436