Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study

W. Ibraheem, W.H. Jedaiba, A.M. Alnami, L.A. Hussain Baiti, S.M. Ali Manqari, A. Bhati, A. Almarghlani, M. Assaggaf

Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia. gums_ashh@yahoo.com

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• Dentistry

OBJECTIVE: To evaluate the efficacy of 0.2% hyaluronic acid gel and 0.01% hyaluronic acid (HA) spray in the healing of extraction wounds using the ruler and digital planimetry method.

PATIENTS AND METHODS: 30 systemically healthy female participants aged between 20-60 years requiring extraction were selected. Extraction sockets receiving 0.2% HA gel Gengigel®, 0.01% HA spray Gengigel®, and where hyaluronic acid was excluded were allocated into three groups as test group A (HA gel group), test group B (HA spray group) and control group (without HA). Socket wound closure was measured post-operative on the day of extraction and 1-week post extraction using digital planimetry and ruler method. Patient satisfaction rate was evaluated for both the gel and spray.

RESULTS: The wound closure with the ruler method was 43.01% for the control group, 67.01%, and 65.82% for the gel group and spray group respectively. The wound closure with the digital planimetry method was 47.97% for the control group, 69.08% for the gel group, and 66.94% for the spray group. The gel showed better results of wound closure as compared to the spray. However, the results were not statistically significant.

CONCLUSIONS: Hyaluronic acid offers a beneficial effect in early post-operative healing after extraction.

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