A short review on cervical cancer cell lines characterization and their corresponding human leukocyte antigen (HLA) type expression

R.S. Rajan, S.A. Dass, G.J. Tye, V. Balakrishnan

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia. venugopal@usm.my

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• Gynecology
• Immunology
• Oncology

Cervical cancer is one of the leading causes of death in women worldwide. Extensive research is ongoing to develop efficient diagnostics and therapeutic approaches for cervical cancer, which rely on the preliminary studies based on cervical cell lines. It is essential to characterize these cell lines to ensure the suitability of the cells for each study. In this review, the human leukocyte antigen (HLA) molecule expressed on each cervical cancer line is presented. HLA characterization of the cervical cancer cell lines is essential to increase the specificity of treatment towards certain type of cervical cancer, allowing accurate therapy. HLA characterization is also important for the generation of novel diagnostics and/or therapeutics molecules, especially for HLA-based strategies.

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