Acrokeratosis of Bazex as a sign of thyroid cancer: first description and review of thyroid-associated paraneoplastic dermatoses

L. Macca, L. Manuella, R. Taibi, C. Guarneri

Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy C/O A.O.U.P. “Gaetano Martino”, Messina, Italy. cguarneri@unime.it

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• Dermatology
• Endocrinology

OBJECTIVE: Bazex syndrome is a rare paraneoplastic skin disorder of unknown pathogenesis. Cutaneous findings are usually noticed before the diagnosis of the underlying malignancy, more frequently squamous cell carcinomas of the upper aerodigestive tract or metastasis to cervical lymph nodes. Association with other malignancies has been reported.

CASE REPORT: Herein, we describe a case in course of metastatic papillary thyroid carcinoma and review the relevant literature.

RESULTS: A bibliographic search was conducted and a total of 8 studies concerning the association were reviewed.

CONCLUSIONS: Physicians be aware of unexpected cutaneous conditions as a possible sign of underlying tumors.

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