OBJECTIVE: The aim of our study was to present the clinical alterations of CRP, LDH, neutrophil to lymphocyte ratio, platelets to lymphocyte ratio, D-dimer, blood gas analyses, vitamin D, VEGF, IL-6, IFN-γ, CD4+, CD8+) and their correlation with oxidative stress index (OSI) in hospitalized COVID-19 patients.
PATIENTS AND METHODS: Oxidative stress index and clinical parameters were determined at admission and/or 7 days after hospitalization in 50 patients divided in moderate and severe group.
RESULTS: In the moderate group of patients, a good correlation (R2 = 0.7400, p<0.05) was found between OSI and PLR, D-dimers and LDH at admission and after 7 days. The OSI correlated well with vitamin D, INF-γ, IL-6, CD4+, CD8+ and the absolute CD8 cell number on admission (R2=0.7635, p<0.05). Vitamin D deficiency (15.37 ng/mL ± 2.81) was observed at admission in the severe group, accompanied by increased levels of IL-6 (295.3 pg/mL ± 40.06), INF-γ (1.603 pg/mL ± 0.134), VEGF (546.8 pg/mL ± 124.2) compared to non-infected individuals. All patients had low partial pressure of oxygen, although it did not show statistically significant difference between the two groups.
CONCLUSIONS: All investigated parameters were altered in both groups of patients and a good correlation between them was demonstrated.Free PDF Download
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To cite this article
D. Zendelovska, M. Petrushevska, E. Atanasovska, K. Spasovska, K. Gjorgjievska, K. Pavlovska, K. Grozdanovski
COVID-19 disease induced alteration of oxidative stress and clinical laboratory parameters in moderate and severe patients
Eur Rev Med Pharmacol Sci
Vol. 26 - N. 15