COVID-19 disease induced alteration of oxidative stress and clinical laboratory parameters in moderate and severe patients

D. Zendelovska, M. Petrushevska, E. Atanasovska, K. Spasovska, K. Gjorgjievska, K. Pavlovska, K. Grozdanovski

Institute of Preclinical and Clinical Pharmacology and Toxicology, University of Ss Cyril and Methodius, Faculty of Medicine, Skopje, Republic of North Macedonia. marija.petrusevska@medf.ukim.edu.mk

 

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• Infectious Diseases
• Laboratory Medicine

OBJECTIVE: The aim of our study was to present the clinical alterations of CRP, LDH, neutrophil to lymphocyte ratio, platelets to lymphocyte ratio, D-dimer, blood gas analyses, vitamin D, VEGF, IL-6, IFN-γ, CD4+, CD8+) and their correlation with oxidative stress index (OSI) in hospitalized COVID-19 patients.

PATIENTS AND METHODS: Oxidative stress index and clinical parameters were determined at admission and/or 7 days after hospitalization in 50 patients divided in moderate and severe group.

RESULTS: In the moderate group of patients, a good correlation (R2 = 0.7400, p<0.05) was found between OSI and PLR, D-dimers and LDH at admission and after 7 days. The OSI correlated well with vitamin D, INF-γ, IL-6, CD4+, CD8+ and the absolute CD8 cell number on admission (R2=0.7635, p<0.05). Vitamin D deficiency (15.37 ng/mL ± 2.81) was observed at admission in the severe group, accompanied by increased levels of IL-6 (295.3 pg/mL ± 40.06), INF-γ (1.603 pg/mL ± 0.134), VEGF (546.8 pg/mL ± 124.2) compared to non-infected individuals. All patients had low partial pressure of oxygen, although it did not show statistically significant difference between the two groups.

CONCLUSIONS: All investigated parameters were altered in both groups of patients and a good correlation between them was demonstrated.

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