Eur Rev Med Pharmacol Sci 2022; 26 (16): 5676-5682

DOI: 10.26355/eurrev_202208_29501

MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease

E. Yaşar, T. Çakmak, A. Bayramoğlu, Y. Karakuş, S. Tekin, G. Şekerci, C. Türkoğlu

Department of Cardiology, Malatya Training and Research Hospital, Malatya, Turkey. erdi004@gmail.com


OBJECTIVE: Atherosclerosis plays a major role in the development of coronary artery disease (CAD). It has been shown that mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c), a mitochondrial-derived peptide, has preventive effects on atherosclerosis. The aim of this study was to determine the relationship between MOTS-c levels and CAD presence and severity using SYNTAX score (SS) in patients with stable angina pectoris.

PATIENTS AND METHODS: Ninety-two consecutive patients with stable coronary artery disease (CAD+) and ninety-two consecutive patients with normal coronary artery (CAD-) were included. Presence and severity of coronary artery disease were determined using the SS.

RESULTS: We observed that the MOTS-c levels was lower in the CAD group (111±13 vs. 161±23, p<0.001). The MOTS-c levels were also found to be significant independent predictors for CAD in multiple regression analysis (p<0.001). A MOTS-c levels ≥130.9 had 80.3% sensitivity and 73.2% specificity (area under the curve [AUC]: 0.858, 95% CI: 0.895-0.999, p<0.001) for predicting CAD.

CONCLUSIONS: The authors revealed that there is a strong correlation between MOTS-c levels and CAD. Therefore, MOTS-c may help identify patients with CAD, thus allowing for early preventive treatment.

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E. Yaşar, T. Çakmak, A. Bayramoğlu, Y. Karakuş, S. Tekin, G. Şekerci, C. Türkoğlu
MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease

Eur Rev Med Pharmacol Sci
Year: 2022
Vol. 26 - N. 16
Pages: 5676-5682
DOI: 10.26355/eurrev_202208_29501