Eur Rev Med Pharmacol Sci 2022; 26 (17): 6340-6343

DOI: 10.26355/eurrev_202209_29659

Inhibitory mechanism of ternary fusion protein MSIK on HPV virus

H.-F. Hu, Q.-H. Zhao, Y.-F. Sang

Affiliated Hospital, Hunan Polytechnic of Environment and Biology, Hengyang, China. huhengfenfen@126.com


OBJECTIVE: We investigated whether the ternary fusion protein (MBP-SERPINA3-IFN-κ, MSIK) can inhibit the proliferation of human papillomavirus (HPV) and the possible mechanism of this inhibitory effect.

MATERIALS AND METHODS: First, the purchased MSIK protein was prepared into MSIK protein solutions of different concentrations, and then epithelial cells and 300 mice were involved in the research. The HSV-1 virus was used as the infection pathogen to explore the mechanism of MSIK reinhibition of HPV virus. The virus content in each sample was detected by PCR technology.

RESULTS: Epithelial cells treated with different concentrations of MSIK had inhibitory effects on the invasion and replication of HSV-1 virus. MSIK protein had a positive effect on wound healing in mice at the same time, and it had an inhibitory effect on the invasion of HSV-1 virus, and the higher concentration of MSIK, the better the effect.

CONCLUSIONS: MSIK can quickly help wound healing and inhibit the replication of HSV-1 virus. It can also effectively prevent the influx of HPV virus and replication has a positive effect on the prevention and treatment of HPV virus.

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To cite this article

H.-F. Hu, Q.-H. Zhao, Y.-F. Sang
Inhibitory mechanism of ternary fusion protein MSIK on HPV virus

Eur Rev Med Pharmacol Sci
Year: 2022
Vol. 26 - N. 17
Pages: 6340-6343
DOI: 10.26355/eurrev_202209_29659