Hyperinsulinemia/insulin resistance is a well-known feature of polycystic ovarian (PCO) syndrome. In this study, the comparative roles of the peripheral tissues and the pancreatic beta-cells in its pathogenesis were evaluated. We determined basal serum C-peptide values (index of insulin secretion) and in vivo insulin action on peripheral glucose utilization (by the euglycemic hyperinsulinemic clamp technique) in obese (n=5) and nonobese (n=5) PCO women compared to obese (n=5) and nonobese (n=5) normal ovulatory women.
During the clamp, feedback inhibition of insulin on insulin secretion was studied by C-peptide percentage suppression. Serum C-peptide basal values did not differ significantly between the four groups. Insulin stimulated glucose utilization, expressed as M-value, was significantly decreased in both PCO groups compared to normal ovulatory women (p<0.005). The metabolic clearance rate of glucose (MCR) and insulin (M/I) had the same behaviour. No differences were found between M, MCR and M/I values and the two groups of PCO subjects (obese/nonobese). The C-peptide percentage suppression was similar in all the groups. We conclude that PCO women have a significant insulin resistance that is indipendent of obesity, while basal and insulin-inhibited insulin secretion do not differ from normal-cycle subjects.Free PDF Download
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D. Sinagra, A.M. Scarpitta, M. BrigandÌ, G. D’acquisto
Feedback inhibition of insulin secretion and insulin resistance in polycystic ovarian syndrome with and without obesity
Eur Rev Med Pharmacol Sci
Vol. 1 - N. 5