Eur Rev Med Pharmacol Sci 2022; 26 (24): 9126-9143
DOI: 10.26355/eurrev_202212_30663

Role of antioxidants in preventing testicular ischemia‑reperfusion injury: a narrative review

Z.-M. Li

Department of Pharmacology, The First Hospital of Yulin, Yulin, Shaanxi, China. lizhimei1207@qq.com

Testicular ischemia-reperfusion injury (TIR) is a urological emergency common among male newborns, children, and adolescents. Testicular injury and its consequences, such as altered hormone production, subfertility, and infertility, are determined by the duration and degree of testicular torsion. Early diagnosis and treatment are crucial to preserving the testes and fertility. Previous studies suggest that reactive oxygen species contribute to the pathogenesis of TIR injury, but the underlying mechanism remains unclear. Several drugs/plants reportedly exhibit antioxidative activities to protect against TIR. This review summarizes current studies on the role of antioxidants in preventing experimental TIR injury and discusses the underlying pathophysiological mechanisms.

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To cite this article

Z.-M. Li
Role of antioxidants in preventing testicular ischemia‑reperfusion injury: a narrative review

Eur Rev Med Pharmacol Sci
Year: 2022
Vol. 26 - N. 24
Pages: 9126-9143
DOI: 10.26355/eurrev_202212_30663

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