Changes in integrins αv and α5 with Nogo-A in the rat retina after optic nerve injury

X.-L. Yin, J.-P. Zhang, J. Ye, Y. Huo, X.-X. Li, Z.-P. Liu, X.-M. Liang

Department of Ophthalmology, Department of Medical Administration, The 305 Hospital of PLA, Beijing, China. yinxiaolei971221@163.com

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• Ophthalmology

OBJECTIVE:  The purpose of this study was to investigate whether integrin levels are associated with axon regeneration after central nervous system (CNS) injury.

MATERIALS AND METHODS: By using immunohistochemistry, we performed a detailed investigation of the changes in and colocalization of integrins αv and α5, with Nogo-A in the retina after optic nerve injury.

RESULTS: We confirmed that integrins αv and α5 were expressed in the rat retina and colocalized with Nogo-A. After optic nerve transection, we found that integrin α5 levels increased over 7 days, but integrin αv levels remained unchanged, while Nogo-A levels increased.

CONCLUSIONS: It seems that the inhibition of axonal regeneration by the Amino-Nogo-integrin signaling pathway may not occur via changes in integrin levels.

 

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