Eur Rev Med Pharmacol Sci 2023; 27 (7): 3082-3087
DOI: 10.26355/eurrev_202304_31942

Role of cited-1 and caspase-6 expression in HELLP syndrome

E. Öcal, S. Alkan Akalın, F. Aşır

Division of Perinatology, Private Medical Practice, Diyarbakir, Turkey. firatasir@gmail.com


OBJECTIVE: In this study, we investigated the immunohistochemical staining of cited-1 and caspase-6 expression in the placentas of pregnant women with HELLP syndrome.

PATIENTS AND METHODS: Placentas of 20 normotensive patients and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and cited-1 and caspase-6 immunostaining.

RESULTS: Placentas of normotensive patients showed normal histology. Placentas of women with HELLP syndrome showed degenerated cells, hyalinization and vacuolization. Cited-1 expression was negative in normotensive group; however, it was increased in HELLP group, especially in decidual cells, endothelial cells and other placental cells. Caspase-6 expression was negative in placental structures of normotensive groups. However, it was intense in decidual cells, vacuolar and hyalinized areas, inflammatory cells and connective tissue cells in HELLP group.

CONCLUSIONS: Cited-1 and caspase-6 are a marker in determining the severity of HELLP syndrome.

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To cite this article

E. Öcal, S. Alkan Akalın, F. Aşır
Role of cited-1 and caspase-6 expression in HELLP syndrome

Eur Rev Med Pharmacol Sci
Year: 2023
Vol. 27 - N. 7
Pages: 3082-3087
DOI: 10.26355/eurrev_202304_31942