Evaluation of Tp-E interval and Tp-E/Qtc ratios in patients with overt hypothyroidism and subclinical hypothyroidism

A. Sari, İ.E. Dural, U. Aksu, C. Korucu, E. Bozkurt, M. Apaydin

Department of Internal Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey. alpersari_@hotmail.com

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• Endocrinology

OBJECTIVE: Tp-e interval and Tp-e/QTc are among the new-generation indicators used for predicting cardiac arrhythmia and ventricular repolarization. In this study, we aimed to evaluate Tp-e and Tp-e/QTc ratios in patients with overt hypothyroidism and subclinical hypothyroid patients.

PATIENTS AND METHODS: In this study, a total of 105 patients were included with 35 overt hypothyroidism, 35 subclinical hypothyroidism, and 35 healthy euthyroid patients. The anthropometric measurements, laboratory results, and electrocardiographic data of the patients were measured. The groups were compared in terms of Tp-e interval, Tp-e/QT and Tp-e QT/c ratios.

RESULTS: When the Tp-e interval and Tp-e/QTc values of the patients were compared, a significant difference was found (p<0.001). A positive correlation was found between thyroid stimulating hormone (TSH) with Tp-e interval and Tp-e/QT ratio.

CONCLUSIONS: Tp-e interval and Tp-e/QTc duration increased in overt hypothyroidism and subclinical hypothyroidism patients compared to euthyroid patients. We believe that regular use of levothyroxine therapy in overt hypothyroidism patients will decrease cardiac mortality. Cardiac risk factors should be considered to decide on levothyroxine therapy for subclinical hypothyroidism patients.

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