Curcumin nanoparticles and the therapeutic potential of curcumin for musculoskeletal disorders

H.-Y. Wu, H.-T. Yu, B. Kang, Y.-Y. Xuan, H.-Q. Zhang, X.-S. Li

Department of Joint Surgery, The 940th Hospital of Joint Logistics Support Force of The Chinese People’s Liberation Army, Lanzhou, Gansu, China. zhanghaoqiang_fmmu@163.com

---

• Orthopedics
• Phytomedicine

Musculoskeletal disorders (MSD) are a collection of degenerative conditions impacting the body’s bones, joints, muscles, tendons, ligaments, and nerves. MSDs affect approximately 1.71 billion individuals worldwide and are a significant cause of disability. Curcumin is a polyphenolic compound with anti-inflammatory, antioxidant, and antitumor properties. In this review, we will discuss the research progress of structural analogs, derivatives, and nanomaterials that can improve the bioavailability of this natural drug. Curcumin may potentially retard the progression of osteoporosis, osteoarthritis, and rheumatoid arthritis. These effects may be related to curcumin’s targeting of multiple signalling pathways.

Free PDF Download