The expression of ferroptosis-related genes in osteoporosis based on GEO

L.-L. Wu, Y.-X. Sui, H.-H. Cong, Z.-Z. Leng, Y.-M. Jia, S. Ao

Department of Spine Surgery, Chifeng Municipal Hospital, Chifeng City, Inner Mongolia, China. 88381441@qq.com

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• Orthopedics

OBJECTIVE: The aim of this study was to screen the differential genes related to ferroptosis in osteoporosis patients.

MATERIALS AND METHODS: GEO2R was used to screen the differential genes related to ferroptosis in osteoporosis patients by searching the relevant chips in the GEO database, and Spearman’s correlation analysis was used to describe the correlation between quantitative variables without normal distribution. p-values lower than 0.05 were considered statistically significant. Another group of osteoporosis patients was selected in the GEO database to verify the significantly differentially expressed genes.

RESULTS: The results showed that 10 samples in chip GSE35956 were identified as research objects, and a total of 5 ferroptosis differential genes were screened out: ATP5MC3, CDKN1A, MT1G, NCOA4, SLC1A5, of which 3 up-regulated genes (CDKN1A, MT1G, SLC1A5), 2 down-regulated genes (ATP5MC3, NCOA4). The above differential genes were placed in 19 samples of chip GSE35959 for verification, and the same expression trend was obtained, but only the MT1G difference was statistically significant.

CONCLUSIONS: The gene correlation test found that MT1G and ATP5MC3 had a strong negative correlation.

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